RESEARCH AREAS
In the intersection of aging and psychiatry, GAPsLab will concentrate on three primary areas (listed below). Additionally, we always encourage projects that align with students' interests.
Depression and Alzheimer's Disease
Supported by National Institute of Aging K99/R00
Alzheimer’s disease (AD) is a common form of dementia that affects memory and cognitive function. By 2050, over 13 million people are projected to suffer from AD. Studies have shown that depression can precede AD by many years and is prevalent in those with mild cognitive impairment (MCI), an early stage of AD. This study aims to explore the genetic and epigenetic links between depression and AD using data from multiple large cohorts, with the goal of identifying mechanisms and potential treatment targets.
Alcohol Use Disorder and Alzheimer's Disease
Supported by Alzheimer's Association Postdoctoral Fellowship
Alzheimer's disease (AD) and alcohol use disorder (AUD) are significant public health concerns, impacting millions of people worldwide. By 2050, nearly 13 million Americans are expected to have AD, while AUD currently affects about 28.8 million U.S. adults. Alcohol use worsens brain damage and cognitive decline through processes like increased oxidative stress and brain inflammation. Epigenetic changes, such as DNA methylation, linked to alcohol use, can lead to accelerated biological aging, increasing the risk of developing AD. Therefore, this study aims to understand how these conditions interact on genetic and epigenetic levels for improving prevention and treatment strategies.
Supported by Yale Women's Faculty Forum Award, American Heart Association GWTG Travel Award
Post-traumatic stress disorder (PTSD) and depression are significant mental health concerns that often arise following trauma exposure. While the primary impact of PTSD and depression is on mental well-being, emerging evidence indicates that these psychiatric disorders also have profound effects on physical health, particularly cardiovascular health. The stress and emotional dysregulation linked to these conditions can lead to increased inflammation, higher blood pressure, and other physiological changes that strain the cardiovascular system. Despite this, there remains a substantial gap in our understanding of how PTSD and depression contribute to cardiovascular risks. This study investigates omics and medical records to understand effects of mood disorders on cardiovascular system.
